DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC50 of ∼0.1-0.4 μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9.

Product information

CAS Number: 672286-03-2

Molecular Weight: 332.16

Formula: C11H7Cl2N3O3S

Chemical Name: 1-(2,6-dichlorophenyl)-3-(5-nitrothiophen-3-yl)urea

Smiles: [O-][N+](=O)C1=CC(=CS1)NC(=O)NC1C(Cl)=CC=CC=1Cl

InChiKey: AATXXTHMITUAOJ-UHFFFAOYSA-N

InChi: InChI=1S/C11H7Cl2N3O3S/c12-7-2-1-3-8(13)10(7)15-11(17)14-6-4-9(16(18)19)20-5-6/h1-5H,(H2,14,15,17)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (376.32 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

DFP00173 inhibits the glycerol permeability of human erythrocytes with an IC50 of ~0.2 µM.

Products are for research use only. Not for human use.